Nanodiamonds: Advanced carriers for anticancer drug delivery / Pritam Mukherjee, Indu Singh
Bibliogr.: p. 43-44. - Abstr. eng. - DOI: https://doi.org/10.33892/aph.2023.93.34-44
In: Acta Pharmaceutica Hungarica. - ISSN 0001-6659. - 2023. 93. évf. 1. sz., p. 34-44.
Abstract: Diamond nanoparticles discovery and extensive applications in modern biosciences. Because of its excellent biocompatibility, it serves as useful platforms that can be implanted within polymer-based microfilm devices. Nanodiamonds complex with a chemotherapeutic show sustained release of the drug for a month, with a significant amount of drug in reserve. It serves the potential for highly localized drug release as a complementary and potent form of treatment with systemic injection towards the reduction of continuous dose, and as such, attenuation of the often-powerful side effects of chemotherapy. Nano-diamonds are very economical, allowing the wide impact of these devices for a range of physiological disorders like supporting as a local chemotherapeutic patch, or as a pericardial device to suppress inflammation after open heart surgery. Nano-diamond patch could be used to treat a localized region where residual cancer cells might remain after a tumour is removed. Nano-diamonds may be used to discover a wide range of therapeutic classes, including small molecules, proteins, therapeutic antibodies, RNAi. Kulcsszavak: Nanodiamonds, nanoparticles, tumour, therapeutics, proteins