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Részletek

A cikk állandó MOB linkje:
http://mob.gyemszi.hu/detailsperm.jsp?PERMID=151700
MOB:2021/2
Szerzők:Benke Edit; Szabó-Révész Piroska; Ambrus Rita
Tárgyszavak:GYÓGYSZERALKALMAZÁS, INHALÁCIÓS; GYULLADÁSGÁTLÓK, NEMSZTEROID; PULMONOLÓGIA
Folyóirat:Acta Pharmaceutica Hungarica - 2021. 91. évf. 2. sz.
[https://www.aph-hsps.hu/acta/index.php/aph/issue/archive]


  Development of meloxicam potassium-containing co-spray-dried inhalation powder with sodium stearate  / Edit Benke, Piroska Szabó-Révész, Rita Ambrus
  Bibliogr.: p. 81-82. - Abstr. eng. -  DOI: https://doi.org/10.33892/aph.2021.91.75-82
  In: Acta Pharmaceutica Hungarica. - ISSN 0001-6659. - 2021. 91. évf. 2. sz., p. 75-82. : ill.


Pulmonary drug delivery (PDD) has potential for both local and systemic therapy. Our research group is focus- ing on the development of dry powder inhalation (DPI) systems for PDD due to their beneficial properties. Although there is not yet a marketed inhalation product for non-steroidal anti-inflammatory drugs (NSAIDs), their therapeutic use in sev- eral lung diseases is well established and successful DPI developments have been performed with them. Sodium stearate (NaSt) is a promising excipient for DPI development, but its role in NSAIDs has not yet been investigated. Thus, the aim was to study DPI samples produced by co-spray-drying, applying meloxicam potassium (MXP) as an NSAID drug, and different concentrations (0-2 w/w%) of NaSt. Physicochemical investigations, in vitro lung deposition, and in vitro drug release measurements were performed. It can be stated that co-spray-drying of MXP with NaSt resulted in remarkable morphological differences by increasing the concentration of NaSt, which had a positive effect on cohesive work. Further- more, applying of NaSt accelerates the dissolution in simulated lung fluid (SLF). NaSt as excipient has a future for the formulation of the DPI systems because there are in the development focus the attaintment of the higher FPF values and improvement of dissolution in SLF.  Kulcsszavak: pulmonary drug delivery, dry powder inhaler, meloxicam potassium, sodium stearate, aerodynamic properties