Acute gastroenteritis is a major contributorto child mortality, with rotavirus emerging as a prominent pathogen. Rotavirus primarily targets the enterocytes of the small intestine, traditionally causing gastrointestinal symptoms. Over the past decade, however, rotavirus infection has been recognized as a multifaceted disease with systemic effects. Commonly aflected systems include the respiratory tract, liver, central nervous system, and fluid and ion balance. 0ur first case involved an 8-month-old inlant who arrived at our clinic in a state of hypovolemic shock characterized by severe dehydration, requiring initial parenteral therapy via an intraosseous cannula. The second case was a one-year-old boy who presented in a precarious condition. 0n initial assessment we noted respiratory and central nervous system symptoms as well as gastrointeslinal involvement. His viral infection resulted in a significant weight loss ol 23%. The third case, an 8-month-old infant, had a marked electrolyte imbalance despite adequate oral fluid intake during hospitalization. The fourth child presented in a similarly poor general condition. lnitial laboratory abnormalities raised concerns for diabetes, and although neuroinfection was suspected due to seizures, this remained unconlirmed. 0n the third day of hospitalization, significantly elevated liver enzymes were consistent with Rota-associated hepatitis. Ultimately, the transient liver lailure was attributed to hypoxic-ischemic failure as the underlying cause. These selected cases lrom the last 1.5 years at our hospital illustrate the most common extraintestinal manifestations of rotavirus infection. ln young children, life-threatening conditions can develop rapidly, underscoring the critical importance of passive immunization.  Kulcssszavak: Rotavirus infection, extraintestinal manifestations, infant