Purpose: We present a summary of a PhD thesis focusing on the prevention of disease progression after an episode of acute pancreatitis (AP). Methods: Using the Hungarian Pancreatic Study Group AP Registry, we performed a cohort analysis comparing AP patients with and without a family history of pancreatic disease, comparing the prevalence ol idiopathic etiology, diabetes, hyperlipidemia, alcohol consumption, and smoking. We performed a systematic review of all available data on individuals with concomitant AP and coronavirus disease 2019 (COVlD-19) and discussed the possible cause-effect relationship. Finally, we designed the protocol and initiated the enrollment of a randomized controlled trial (RCT) comparing two diets with dilferent fat content after idiopathic AP to evaluate the effect on AP recurrence and progression to chronic pancreatitis (CP). Results: ln our cohort analysis, idiopathic AP peaked in childhood in the positive family history group (75% 0-5 years) and was consistenly 20-BST' in the negative group. Higher rates of alcohol consumption/smoking were found in the positive groups at 12-17 years (62,5% vs. 15.8%; P=0.013) and 18-29 years (90.9% vs. 581%; P=0.049). Six case reports were eligible for inclusion in our systematic review. Conclusions: ln patients with AB a positive family history most likely indicates a genetic background in early childhood and may indicate alcohol consumption and smoking in adolescents and young adults. All case reports included in our systematic review were of poor quality and performed inadequate etiologic workup, based on which the AP causative role of COVID-19 cannot be confirmed. lf our RCT proves the efficacy of dietary fat reduction, it will be the first known intervention to prevent disease progression in idiopathic AP  Kulcsszavak: Pediatric pancreatitis, recurrent pancreatitis, dietary fat, family history, C0VID-19, SARS-CoV-2