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Részletek

A cikk állandó MOB linkje:
http://mob.gyemszi.hu/detailsperm.jsp?PERMID=165643
MOB:2024/4
Szerzők:Mese, Kemal; Rosado, Esther Maguilla; Lüder, Carsten G. K.; Abdel-Moneim, Ahmed Sayed; Jordan, Patrick; Schwanbeck, Julian; Bunz, Oskar; Lugert, Raimond; Bohne, Wolfgang; Gao, Jian; Dudakova, Anna; Groß, Uwe; Zautner, Andreas E.
Tárgyszavak:SARS-COV-2; KORONAVÍRUS; MONOCYTÁK; ANTITESTEK
Folyóirat:European Journal of Microbiology and Immunology - 2024. 14. évf. 4. sz.
[https://akjournals.com/view/journals/1886/1886-overview.xml]


  FcyRIIa-mediated antibody-dependent uptake of SARS-CoV-2 enhances IL-6 expression of monocytes / Kemal Mese [et al.]
  Bibliogr.: p. 389-391. - Abstr. eng. - DOI: https://doi.org/10.1556/1886.2024.00109
  In: European Journal of Microbiology and Immunology. - ISSN 2062-509X . - 2024. 14. évf. 4. sz., p. 380-391. : ill.


This work aimed to investigate interactions between antibody-opsonized SARS-CoV-2 and monocytes enriched from human peripheral blood mononuclear cells (PBMC) to determine whether antibody dependent enhancement might contribute to the pathophysiology of COVID-19. Pre-incubation of SARS-CoV-2 with sera from hospitalized COVID-19 patients led to significantly increased virus uptake and viral replication in monocytes. Remarkably, SARS-CoV-2 pre-incubated with sera from patients with severe COVID-19 but not those with mild disease or post vaccination strongly increased IL-6 secretion by monocytes. Antibody dependent viral uptake was partially inhibited by monoclonal anti-FcăRIIa antibody whereas IL-6 secretion was completely abolished. FcăRIIa preferentially binds IgG2, and sera from patients with severe COVID-19 contained lower IgG2 levels as compared to mild COVID-19 cases whereas IgG1 levels were increased. These data suggests that FcăRIIa-mediated binding of antibody-opsonized SARS-CoV-2 critically impacts monocytic inflammatory cytokine release and COVID-19 pathophysiology.  Kulcsszavak: SARS-CoV-2, FcăRIIa, monocytes, IL-6, ADE