MOB: | 2024/4 |
Szerzők: | Glyschewski, Lynn; Hahn, Andreas; Rohde, Holger; Lütgehetmann, Marc; Feldt, Torsten; Sarfo, Fred Stephen; Phillips, Richard Odame; Dompreh, Albert; Asibey, Shadrack Osei; Boateng, Richard; Weinreich, Felix; Frickmann, Hagen; Eberhardt, Kirsten Alexandra |
Tárgyszavak: | HIV; HEPATITIS B; HEPATITIS C |
Folyóirat: | European Journal of Microbiology and Immunology - 2024. 14. évf. 4. sz. [https://akjournals.com/view/journals/1886/1886-overview.xml] |
Replicative co-infections with human immunodeficiency virus 1 and 2 as well as hepatitis B and C virus in Ghanaian individuals / Lynn Glyschewski, Glyschewski, Lynn
Bibliogr.: p. 357. - Abstr. eng. - DOI: https://doi.org/10.1556/1886.2024.00103
In: European Journal of Microbiology and Immunology. - ISSN 2062-509X . - 2024. 14. évf. 4. sz., p. 346-360. : ill.
Background: The study assessed replicative human immunodeficiency virus-(HIV-) infection and replicative co-infections as well as molecular determinants of reduced susceptibility towards anti-retroviral therapy in a Ghanaian population of known HIV patients and a control group. Methods: Real-time PCRs for HIV-1, HIV-2, hepatitis B virus (HBV) and hepatitis C virus (HCV) were run with serum samples from known Ghanaian HIV-patients (n 5 975) and control individuals (n 5 105). For 108 individuals, HIV-sequence analysis was performed. Results: Prevalence of replicative HIV-1 infection was 59.8% (583/975) in the known HIV-positive population and 2.9% (3/105) in the controls. Prevalences of replicative HBV-infection were comparable with 3.4% (33/975) in the HIV-positive individuals and 3.8% (4/105) in the controls. HIV-2 and HCV sequences were not recorded. Almost perfect concordance between two compared HIV-1-PCR assays was indicated by Fleiss? Kappa >0.8. Sanger sequencing indicated CRF_02AG, G and A3 as the quantitatively dominating HIV-1 subtypes, a minority of 3.4% CXCR4 tropism and high detection rates of mutations mediating reduced susceptibility towards nucleoside reverse transcriptase inhibitors (71.9%, 64/89), non-nucleoside reverse transcriptase inhibitors (95.5%, 85/89), protease inhibitors (95.9%, 93/97) and integrase inhibitors (22.4%, 22/98). Conclusions: The assessment did not suggest HIV-triggered increased replication of HBV and HCV in the investigated Ghanaian population. Kulcsszavak: human immunodeficiency virus, hepatitis B virus, hepatitis C virus, Ghana, epidemiology, co-infection, chronic infection, resistance, genotypes, sequencing