Since last year's report in the European Heart Journal, we have witnessed substantial progress in all aspects of interventional cardiology. Of note, the practice of interventional cardiology took place amidst successive waves of the COVID-19 pandemic, which continues to be a major burden for all healthcare professionals around the globe. In our yearly review, we shall revisit the developments in percutaneous coronary intervention (PCI), structural heart interven­tions, and adjunctive pharmacotherapy (Graphical Abstract). Kulcsszavak: international cardiology, coronary interventions, transcatheter aurtic valve implantation, antiplatelet agents