We aimed to examine the effects of brain ischemia-reperfusion (IR) especially on serum parameters or liver enzymes, free radicals, cytokines, oxidatively damaged DNA, spermidine/spermine N-1-acetyltransferase (SSAT). The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidantantioxidant balance in liver. The study was conducted on 46 male Albino Wistar rats weighing 200.250 g. The rats were grouped into: 1-Sham group (n 5 6). 2-IR group (n 5 8): The carotid arteries were ligated for 30-min and reperfusion was achieved for 30-min under general anesthesia. 3-Ischemia t putrescine t reperfusion group (IPR) (n 5 8): Unlike the IR group, a single dose of 250 mikromol kg-1 putrescine was given by gavage at the beginning of reperfusion. In putrescine treatment groups in addition to the procedures performed in the IR group a total of 4 doses of 250 mikromol kg-1 putrescine were given at 12-h intervals, with the first dose immediately after 30-min reperfusion (4-IRtputrescine group (IRtP1) (n 5 8)); 3 h after the 30-min reperfusion (5-IRtputrescine group (IRtP2) (n 5 8)); 6 h after the 30-min reperfusion (6-IRtputrescine group (IRtP3) (n 5 8)). ALT, AST, ATP, NO, SSAT, 8-OHdG levels were analyzed in the serum, and liver samples. NF-kB and IL-6 levels were analyzed in the liver samples. Brain IR causes inflammatory, oxidative and DNA damage in the liver, and putrescine supplementation through gavage reduces liver damage by showing anti-inflammatory and antioxidant effects.  Kulcsszavak: ATP, Brain Ischemia-Reperfusion, liver, IL-6, NF-kB, NO, putrescine, rat, SSAT, 8-OHdG