Introduction: Vital exhaustion and the well-being of helping professionals are important issues regarding the sustainability of services, especially in a critical situation such as the COVID-19 pandemic. Aims: The purpose of this study was to investigate helping professionals' vital exhaustion and well-being, concerning different groups of background variables during the COVID-19 pandemic. Methods: In the spring of 2020, Hungarian helping professionals (N = 931) were contacted with an online questionnaire. Results: Our results show that indicators of physical well-being are strongly associated with vital exhaustion and subjective well-being (sleeping quality (X2 (2) = 251.062, p < .001); frequency of meals (X2 (2) = 99.454, p < .001)). Health and social care workers were more exhausted than members of other helping professions (X2(4) =37.782, p < .001). There were statistically significant negative correlations between the Vital Exhaustion and Well-being Score and satisfaction with work conditions (rs (929) = -.418, p < .001), satisfaction with family life (rs (806) = -.342, p < .001) and its change (rs (807) = -.287, p < .001), family-work balance (rs (675) = -.444, p < .001) and its change (rs(786) = -.515, p < .001). In the prediction of the Vital Exhaustion and the Well-being Score, the addition of physical well-being indicators to the regression model led to the strongest increase in R2 of .344, p < .001. Conclusion: A clear and consensual framework for life and work provides security amid unpredictable external changes.  Kulcsszavak: vital exhaustion, well-being, health care workers, social workers, helping professionals