Throughout the history of surgical procedures, a variety of compounds and methods?topical, local, and inhalation anesthetics?have been used to reduce pain, including dental pain. However, the most significant milestone in this history occurred on October 16, 1846, when the first public demonstration of ether anesthesia was performed at Massachusetts General Hospital. Kulcsszavak: general anesthesia, local anesthesia, nitrous oxide, ether, chloroform