Cytomegalovirus (CMV), a member of the herpesvirus family, is a common opportunistic infection affecting the global population. Depending on health, economic, and social factors, CMV prevalence ranges between 45% and 100% of the population. While it primarily causes severe complications in immunosuppressed patients, it can also affect immunocompetent individuals, often asymptomatically. Although central nervous system involvement is rare, it can lead to serious complications. Brain abscesses co-infected with CMV are uncommon, and co-infection with Staphylococcus aureus has not been previously reported. Here, we present the case of a 53-year-old immunocompetent male with a history of type 2 diabetes mellitus, endocarditis, and mitral valve replacement surgery, who was admitted to the hospital with left limb weakness. Imaging revealed a brain abscess, and PCR tests confirmed the presence of S. aureus and CMV. This case report discusses the medical management during his hospitalization.  Kulcsszavak: cytomegalovirus, brain abscess, Staphylococcus aureus, immunocompetent, infections