The aim of our presentation is to show the infections caused by Streptococcus pyogenes, as confirmed by hemocultures during the falt-winter period of last year in our hospital. In addition, the antibiotic resistance of the pathogen will be compared with the efficacy of empirically administered agents. Streptococcus pyogenes is a Gram-positive bacterium that can cause a variety of non-invasive and invasive diseases. It can be classified by its hemolytic properties, carbohydrate-type antigen on the cell surface, and genetic variations. Adhesion of virulence factors to the epithelial cell allows for deeper tissue destruction and dissemination. The treatment of non-invasive and invasive Group A Streptococcal (GAS) infections remains antibiotic therapy, primarily /3-lactams, or vancomycin in allergic cases. In cases of toxin production, treatment is supplemented with clindamycin. In addition, intravenous polyvalent immunoglobulin may be given to neutralize exotoxins. In the last two years, followíng the coronavirus disease of 2019 (COVID-19) pandemic, the number of invasive infections caused by Streptococcus pyogenes has increased in both adult and pediatric populations. Several theories have been proposed to explain this phenomenon, including socioeconomic disadvantage, multiple exposure, host immunity, and viral co-infection. For the case presentation, we used the electronic system of our hospital (Hospitaly) and the electronic health service platform. The first IGAS infection presented as toxic shock syndrome (TSS). Our next patient presented with septicemia and seizures. In other cases, Streptococcus pyogenes was the pathogen of severe pneumonia with complications requiring lysis. In aIl cases studied, the pathogen was found to be sensitive to the antibiotic we used. In conclusion, Streptococcus pyogenes infections are increasing in number and invasiveness after the end of the COVID-19 pandemic. Early recognition and targeted antibiotic treatment are important to prevent complications.  Kulcsszavak: Streptococcus pyogenes, streptococcal toxic shock syndrome, convulsion, COVID-19 pandemic