Introduction: Bacteremia is responsible for high rates of morbidity and mortality. The increasing prevalence of multidrug-resistant (MDR) bacteria in intensive care units (ICU) is a growing concern. Hence, prior knowledge of bacterial epidemiology and resistance phenotypes is required to optimize these infections? management. The objective of this study was to determine the epidemiological profile of bacteremia in ICU settings, as well as the place occupied by MDR bacteria in these infections. Methods: It is a prospective study carried out over 10 months on episodes of bacteremia in the ICU of Mohammed V Military Teaching Hospital (Rabat, Morocco). Microorganism growth was detected using fluorescent technology, species identification was based on morphological and biochemical characteristics. Antimicrobial susceptibility testing was performed following the recommendations of the Antibiogram Committee of the French Society of Microbiology (CA-SFM) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results: Among 504 hospitalized patients, sixty-one (12.1%) presented at least one episode of bacteremia. Forty patients (65.6% of bacteremic patients) presented at least one episode of bacteremia due to MDR bacteria. Male gender, cardiovascular diseases, diabetes and previous hospitalization were significant risk factors for the acquisition of MDR bacteremia. Isolated bacteria were mainly Gram-negative bacilli (GNB) (n 5 62; 68.9%) dominated by Acinetobacter baumannii (n 5 19; 21.1%) and Klebsiella pneumoniae (n 5 16; 17.8%). MDR bacteria were represented by multi-resistant Acinetobacter baumannii (n 5 19; 44.2%), extended-spectrum beta-lactamases-producing Enterobacterales (n 5 9; 20.9%) and carbapenemresistant Enterobacterales (n 5 7; 16.3%). Carbapenems (n 5 40; 65.6%), Aminoglycosides (n 5 32; 52.5%) and Polypeptides (n 5 24; 39.3%) were the most used antimicrobials. Mortality rates were 66.6% (n 5 40) and 85% (n 5 43) in patients with non MDR bacteremia and MDR bacteremia respectively. Conclusion: Limiting the spread of MDR bacteria and improving the management of bacteremic patients require continuous monitoring of bacteremia as well as adapting the therapeutic and preventive strategy.  Kulcsszavak: bacteremia, multidrug-resistant bacteria, intensive care unit