Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus / Bernadett Márkus [et al.]
Bibliogr.: p. 174-175. - Abstr. eng. - DOI: https://doi.org/10.1556/030.2022.01744
In: Acta Microbiologica et Immunologica Hungarica. - ISSN 1217-8950. - 2022. 69. évf. 2. sz., p. 171-175. : ill.
Helicobacter pylori is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute H. pylori infection are contradictory. We intended to see whether H. pylori post-infection status has a long-term effect on serum fetuin-A levels in a well-characterized series of systemic lupus erythematosus cases. In this cross-sectional study 117 patients with systemic lupus erythematosus were enrolled. Helicobacter infection status and serum fetuin-A concentration were determined by ELISA and radial immunodiffusion, respectively. H. pylori positive patients had higher serum fetuin-A concentration than negative ones: 517 (456-603) vs. 476 (408-544) mg L1, median (25-75% percentiles), P 5 0.020. No other parameters differed between these groups. During univariate regression analysis fetuin-A levels were associated with Erythrocyte sedimentation rate (ESR), White blood cell count (WBC), C-reactive protein (CRP), serum total protein, albumin, and the SLEDAI index at the time of diagnosis but only serum albumin remained a significant determinant in multivariate regression study. Kulcsszavak: fetuin-A, Helicobacter pylori, infection, systemic lupus erythematosus
