Focused on five points of view (gaining medical knowledge, career building, enhancing, spreading and sharing knowledge, building scientific infrastructure and taking part in public activities) this study presents physicians providing services in the Hungarian Kingdom of the 18th century. These physicians, among them Ferenc Markhot (1708-1792), coming from a noble family of Nyitra County, Northeastern Hungary (now in Slovakia) belonged to the active membership of the European network named as Respublica Litteraria Medica. While using their knowledge gained in foreign academic centres they became significant members, measured also by European standards, of disseminating knowledge in Hungary. Various stages of Markhot's life show a typical pattern that fits to describe similar profiles and career paths of physicians in this era.  Kulcsszavak: Markhot Ferenc, respublica litteraria medica, peregrinatio medica hungarica, 18. századi orvosprofilok, orvosi kapcsolati hálózatok, orvosi tudástermelés