Background and aim: There is only a limited number of major publications on the outcome of interventions for isolated popliteal artery stenosis. The purpose of this study was to report our results on mid-term patency and predictors of restenosis. Patients and methods: This single-center retrospective study included 61 symptomatic patients (males, N 5 33; median age, 65.1 years [IQR, 60.7-71.9 years]; Rutherford grade 4-6, N 5 14) with at least two patent crural arteries, whose atherosclerotic stenoses/occlusions were treated with percutaneous transluminal angioplasty (PTA) or stenting (using self-expanding bare-metal Astron Pulsar stents) between 2011 and 2018. Results: Twenty-six patients had PTA, while 35 underwent stenting. The median follow-up was 29 months (IQR, 10-47 months). The primary patency rates were not significantly different (P 5 0.629) between PTA and stenting groups. Restenosis developed in nine patients (34.6%) in the PTA group, and in 12 (34.3%) in the stenting group. Restenotic lesions required re-intervention in nine cases (100%) in the PTA group, and in eight (66.7%) in the stenting group. Restenosis developed significantly less frequently (P 5 0.010) in patients with a popliteal/P1 stent; the primary patency rates were also significantly better (P 5 0.018) in patients with a popliteal/P1 stent when compared to popliteal/ P2 plus multi-segment stents. Cox regression analysis identified lesion location as a predictor of instent restenosis (HR, 2.5; 95% CI, 1.2-5.5; P 5 0.019). Conclusion: Stenting was not superior when compared to PTA (if selective stenting was not considered as loss of patency). Follow-up should be more thorough in patients undergoing popliteal/ P2 or multi-segment stenting.  Kulcsszavak: popliteal artery, endovascular therapy, PTA, stenting, restenosis, patency